This subsection of the Names and taxonomy section shows the unique identifier assigned by the NCBI to the source organism of the protein. This subsection of the Names and taxonomy section provides information on the name(s) of the organism that is the source of the protein i
#Serial roze siah part 198 code
More information in the GO evidence code guide
#Serial roze siah part 198 manual
Manual validated information which has been generated by the UniProtKB automatic annotation system. This subsection of the Function section specifies the position(s) and type(s) of zinc fingers within the finger i Manual assertion based on experiment in iĬited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 92-282 IN COMPLEX WITH ZINC AND PEPTIDE SUBSTRATE, FUNCTION, INTERACTION WITH KLF10, MUTAGENESIS OF THR-156 LEU-158 LEU-166 AND MET-180. Manually curated information for which there is published experimental evidence. Manual assertion inferred from sequence similarity to i Manually curated information which has been propagated from a related experimentally characterized protein. Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (PubMed: 24809345). GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins (By similarity). Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus. Induces apoptosis in cooperation with PEG3 (PubMed: 10681424). Required for completion of meiosis I in males (PubMed: 11884614). Has some overlapping function with SIAH2 (By similarity). It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling. Confers constitutive instability to HIPK2 through proteasomal degradation. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins.
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